Technical Profile: What Is Pure NMN Powder (β-Nicotinamide Mononucleotide)?
Pure NMN Powder (CAS Number: 1094-61-7, Molecular Formula: C11H15N2O8P) is a naturally occurring nucleotide and the direct enzymatic precursor to Nicotinamide Adenine Dinucleotide (NAD+). As metabolic cellular research accelerates across global scientific institutions, NMN has emerged as the gold-standard active pharmaceutical and nutraceutical raw material for targeted intracellular NAD+ replenishment.
In human physiology, NAD+ levels decline by approximately 50% between young adulthood and middle age. Because native NAD+ exhibits low cell-membrane permeability due to its large molecular size and dual-phosphate charge structure, oral supplementation relies on smaller, highly bioavailable precursor molecules. Pure NMN Powder bypasses extracellular enzymatic degradation via specialized transporters (such as Slc12a8), allowing rapid systemic uptake and direct phosphorylation into active NAD+ inside target tissue cells.
Not all wholesale NMN powders are created equal. Earth Made Nutritions Inc. utilizes a 100% biological enzymatic process modeled after endogenous cellular synthesis. Unlike traditional chemical synthesis—which frequently leaves traces of toxic organic solvents (such as toluene, pyridine, or chloroform) and produces inactive α-NMN optical isomers—our biocatalytic process yields exclusively pure, biologically active β-Nicotinamide Mononucleotide (β-NMN) with zero synthetic solvent residue.
Earth Made Nutritions - Bulk Pure NMN Powder Specification Matrix
Below are the standardized technical specifications for Earth Made Nutritions Inc.'s commercial batches of Pure NMN Powder, engineered to meet strict international pharmacopeial standards for encapsulators, tableting lines, liposomal liquid manufacturers, and functional drink formulators:
| Parameter / Specification Item | Standard Specification Limit | Typical Test Result (Batch Verified) | Analytical Method |
|---|---|---|---|
| Chemical Name | β-Nicotinamide Mononucleotide | Conforms (100% β-Isomer) | 1H-NMR / Structural Identification |
| Purity Assay (Dry Basis) | ≥ 99.0% (Commercial Grade ≥99.5%) | 99.8% – 99.9% | HPLC-UV (Reverse Phase) |
| Appearance & Physical Form | White to Off-White Crystalline Powder | Fine White Powder | Visual Inspection |
| Optical Isomer Pureness | Alpha-NMN: Non-Detectable (< 0.1%) | Not Detected | Chiral HPLC |
| Bulk Density & Tap Density | Bulk: 0.25 - 0.45 g/ml | Tap: 0.40 - 0.65 g/ml | 0.34 g/ml / 0.52 g/ml | USP <616> Method I |
| Particle Size (Mesh Size) | 100% through 80 Mesh (Custom 200 Mesh available) | 99.6% through 100 Mesh | USP <786> Sieving Analysis |
| Loss on Drying (Moisture) | ≤ 1.0% | 0.38% | USP <731> Vacuum Oven 105°C |
| Heavy Metals (Total) | ≤ 5.0 ppm (Pb <0.5, As <0.5, Cd <0.1, Hg <0.1) | < 0.5 ppm Total | ICP-MS (USP <233>) |
| Residual Solvents | Meets USP <467> Requirements (Zero Organic Solvents) | Conforms | Headspace GC-MS |
| Total Aerobic Plate Count | ≤ 1,000 CFU/g | < 10 CFU/g | USP <2021> Microbiological |
| Yeast & Mold | ≤ 100 CFU/g | < 10 CFU/g | USP <2021> Microbiological |
| Pathogenic Microorganisms | E. coli, Salmonella, S. aureus: Negative/10g | Absent | USP <2022> PCR / Culture |
